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| Background: Historically, TRAIL-R2 has been referred to as tumor necrosis factor receptor superfamily member 10B precursor, death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, and CD262 antigen. TRAIL induces apoptosis in various types of malignant cells without affecting normal cells. TRAIL binds to receptors TRAIL-R1, TRAIL-R2, TRAIL-R3, and TRAIL-R4. Upon binding TRAIL the death receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5), signal apoptosis. Specificity: This antibody recognizes human and mouse TRAIL-R2 and detects a band of ~52kDa by Western blot in HL-60 and Jurkat cells and also recognizes a ~100 kD protein that may be a dimer. Formulation: Liquid 200 µg of affinity purified antibody in 10 mM KHPO4, 140 mM NaCl with 0.1 % sodium azide Quality Control: Western blot and/or Immunocytochemistry on cell lines HEK 293 or Jurkat Storage: Freeze at -20 °C or colder. Stable for at least 3 years when stored at -80°C. Avoid freeze/thaw cycles. CIO110P - Blocking Peptide TRAIL-R2 antibody $95 USD/100 µg
Anti-TRAIL-R2 IH of paraffin section human spleen ENLARGE |
For Research Purposes Only |
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Citations and Applications |
| Babu CK, Suwansrinon K, Bren GD, Badley AD, Rizza SA. HIV induces TRAIL sensitivity in hepatocytes. PLoS ONE. 2009;4(2):e4623. Epub 2009 Feb 27. Full Text WB |
| Sanlioglu AD, Korcum AF, Pestereli E, Erdogan G, Karaveli S, Savas B, Griffith TS, Sanlioglu S. TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma. Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):716-23. Abstract IH |
| Aydin C, Sanlioglu AD, Karacay B, Ozbilim G, Dertsiz L, Ozbudak O, Akdis CA, Sanlioglu S. Decoy receptor-2 small interfering RNA (siRNA) strategy employing three different siRNA constructs in combination defeats adenovirus-transferred tumor necrosis factor-related apoptosis-inducing ligand resistance in lung cancer cells. Hum Gene Ther. 2007 Jan;18(1):39-50 Abstract IH |
| Hoffmann O, Priller J, Prozorovski T, Schulze-Topphoff U, Baeva N, Lunemann JD, Aktas O, Mahrhofer C, Stricker S, Zipp F, Weber JR. TRAIL limits excessive host immune responses in bacterial meningitis. J Clin Invest. 2007 Jul;117(7):2004-13. Full Text FC 1:200 dilution |
| Ganten TM, K Hoffmann O, Priller J, Prozorovski T, Schulze-Topphoff U, Baeva N, Lunemann JD, Aktas O, Mahrhofer C, Stricker S, Zipp F, Weber JR. TRAIL limits excessive host immune responses in bacterial meningitis. J Clin Invest. 2007 Jul;117(7):2004-13. Full Text FC |
| Ganten TM, Koschny R, Haas TL, Sykora J, Li-Weber M, Herzer K, Walczak H. Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL. Hepatology. 2005 Sep;42(3):588-97. WB Abstract |
| Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol. 2005 Jan;57(1):34-41. WB Full Text |
| Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH, Walczak H. Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ. 2004 Jul;11 Suppl 1:S86-96. WB Full Text |
| Jin TG, Kurakin A, Benhaga N, Abe K, Mohseni M, Sandra F, Song K, Kay BK, Khosravi-Far R. Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5. J Biol Chem. 2004 Dec 31;279(53):55594-601. WB Full Text |
| LaVallee TM, Zhan XH, Johnson MS, Herbstritt CJ, Swartz G, Williams MS, Hembrough WA, Green SJ, Pribluda VS.2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 2003 Jan 15;63(2):468-75. IH Full Text |
| Higuchi H, Yoon JH, Grambihler A, Werneburg N, Bronk SF, Gores GJ. Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis. J Biol Chem. 2003 Jan 3;278(1):454-61. IC, WB Full Text |
| Higuchi H, Bronk SF, Takikawa Y, Werneburg N, Takimoto R, El-Deiry W, Gores GJ. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J Biol Chem. 2001 Oct 19;276(42):38610-8. IC, WB Full Text |
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