capralogics
Anti-Human CCR5

Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif.  The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid in between the first 2 cysteines.  Historically, chemokine receptor type 5 has been designated C-C chemokine receptor type 5, CC-CKR-5, CCR-5, HIV-1 fusion coreceptor, CHEMR13, and CD195 antigen.

Specificity: This antibody binds to CCR5 receptor on human spleen as determined by immunohistochemistry

Formulation: Liquid. 200 µg of peptide affinity purified IgG in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1% sodium azide

Quality Control: IH of human spleen

Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.

capralogics CCR5

IH of paraffin section of human spleen

Contact Capralogics
antibodyinfo@capralogics.com
FAX 1-413-643-0067
Phone 1-800-975-6866

Product Number CIO114
Amount 200 µg
Price $299 buy online
Host Goat housed at Capralogics
Antigen

Synthetic peptide 3YQVSSPIYDINYYTSEPCQKINVKQIAA30 corresponding to the N-terminal sequence of human CCR5
Purification Peptide affinity purified
Species Cross- Reactivity macaque
Buffer 10 mM KHPO4, 140 mM NaCl
pH 7.2
*
Applications and Protocols  
ELISA (peptide) 1:25,000
Western Blotting (WB)

1:500
Immunocytochemistry (IC) 1:150
Immunohistochemistry (IH) 1:150

For Research Purposes Only

 

CIO114P - Blocking Peptide to Antibody $95 USD per 100 µg
Citations and Applications
Brunn A, Montesinos-Rongen M, Strack A, Reifenberger G, Mawrin C, Schaller C, Deckert M.  Expression pattern and cellular sources of chemokines in primary central nervous system lymphoma. Acta Neuropathol (Berl). 2007 Sep;114(3):271-6. Abstract IH
van Loosdregt J, van Oosterhout MF, Bruggink AH, van Wichen DF, van Kuik J, de Koning E, Baan CC, de Jonge N, Gmelig-Meyling FH, de Weger RA.  The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response.  Circulation. 2006 Oct 10;114(15):1599-607.  Full Text IH
Thirkill TL, Vedagiri H, Douglas GC.  Macaque trophoblast migration toward RANTES is inhibited by cigarette smoke-conditioned medium.  Toxicol Sci. 2006 Jun;91(2):557-67.  Abstract WB
Elhini A, Abdelwahab S, Ikeda K.  Th1 and Th2 cell population in chronic ethmoidal rhinosinusitis: a chemokine receptor assay.  Laryngoscope. 2005 Jul;115(7):1272-7. Abstract IH
Imamura Y, Kurokawa MS, Yoshikawa H, Nara K, Takada E, Masuda C, Tsukikawa S, Ozaki S, Matsuda T, Suzuki N. Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. Clin Exp Immunol. 2005 Feb;139(2):371-8 Full Text IH

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