|
|||||||||||||||||||||||||||||||
Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid between the first 2 cysteines. Historically, human C-X-C chemokine receptor type 4 (CXC-R4) has been designated as Stromal cell-derived factor 1 receptor (SDF-1 receptor), Fusin, Leukocyte-derived seven transmembrane domain receptor (LESTR), LCR1, FB22, NPYRL, HM89, and CD184 antigen. Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this region. This antibody was not tested for cross-reactivity to mouse CXCR4. Formulation: Liquid. 200 µg of peptide affinity purified IgG in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide. Quality Control: Immunohistochemistry on paraffin sections of human spleen cells Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
Immunohistochemistry on paraffin sections of human spleen CIO115P - Blocking Peptide to Antibody $95 USD per 100 µg For Research Purposes Only |
Above: Anti-CXCR4 Inhibition of SDF-Induced Activation of DU145 (left) and SDF-Induced Activiation of DU145 (right) |
||||||||||||||||||||||||||||||
Citations and Applications |
| Fukunaga S, Maeda K, Noda E, Inoue T, Wada K, Hirakawa K. Association between Expression of Vascular Endothelial Growth Factor C, Chemokine Receptor CXCR4 and Lymph Node Metastasis in Colorectal Cancer. Oncology. 2007 Jul 19;71(3-4):204-211 Abstract IH |
| Wehler T, Wolfert F, Schimanski CC, Gockel I, Herr W, Biesterfeld S, Seifert JK, Adwan H, Berger MR, Junginger T, Galle PR, Moehler M. Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease. Oncol Rep. 2006 Dec;16(6):1159-64. Abstract IH |
| Gockel I, Schimanski CC, Heinrich C, Wehler T, Frerichs K, Drescher D, von Langsdorff C, Domeyer M, Biesterfeld S, Galle PR, Junginger T, Moehler M. BMC Cancer. Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma. 2006 Dec 18;6:290. Full Text IH |
| Schimanski CC, Bahre R, Gockel I, Muller A, Frerichs K, Horner V, Teufel A, Simiantonaki N, Biesterfeld S, Wehler T, Schuler M, Achenbach T, Junginger T, Galle PR, Moehler M. Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer. 2006 Jul 17;95(2):210-7. Abstract IH |
| Schimanski CC, Schwald S, Simiantonaki N, Jayasinghe C, Gonner U, Wilsberg V, Junginger T, Berger MR, Galle PR, Moehler M. Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res. 2005 Mar 1;11(5):1743-50 Abstract IH |
Capralogics Home, Chemokine Receptors, Citations, Contact Us, Custom Polyclonal Antibody Services, FAQ, GLP Compliance, Diagnostic Antibody Production, Interleukins, IVD Antibodies, Licenses and Assurances, "Scrapie Free" Goats, Toll-Like Receptors, Quality Commitment, Welcome to Capralogics
