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| Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid between the first 2 cysteines. Historically, mouse C-X-C chemokine receptor type 4 (CXC-R4) has been designated as Stromal cell-derived factor 1 receptor (SDF-1 receptor), Fusin, Leukocyte-derived seven transmembrane domain receptor (LESTR), Pre-B-cell-derived chemokine receptor (PB-CKR), and CD184 antigen. Specificity: This antibody binds to CXCR4 receptor on mouse spleen leukocytes as determined by immunocytochemistry. Formulation: 200 µg per vial in 10 mM KHPO4, 140 mM NaCl pH 7.2 with 1 mg/ml BSA and 0.1% sodium azide. Antibody in formulation without azide is also available. Quality Control: Immunohistochemistry on mouse spleen Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
CIO116P - Blocking Peptide to Antibody $95 USD per 100 µg For Research Purposes Only |
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Citations and Applications |
| Lima E Silva R, Shen J, Hackett SF, Kachi S, Akiyama H, Kiuchi K, Yokoi K, Hatara MC, Lauer T, Aslam S, Gong YY, Xiao WH, Khu NH, Thut C, Campochiaro PA. The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization. FASEB J. 2007 May 23; Epub ahead of print Abstract IH | Schabath H, Runz S, Joumaa S, Altevogt P. CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells. J Cell Sci. 2006 Jan 15;119(Pt 2):314-25. Full Text WB |
| Belmadani A, Tran PB, Ren D, Assimacopoulos S, Grove EA, Miller RJ. The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci. 2005 Apr 20;25(16):3995-4003 Full Text IH |
| Busso N, Wagtmann N, Herling C, Chobaz-Peclat V, Bischof-Delaloye A, So A, Grouzmann E. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Am J Pathol. 2005 Feb;166(2):433-42. Full Text IH |
| Nishiumi F, Komiya T, Ikenishi K. The mode and molecular mechanisms of the migration of presumptive PGC in the endoderm cell mass of Xenopus embryos. Dev Growth Differ. 2005 Jan;47(1):37-48 Abstract IH |
| Tran PB, Ren D, Veldhouse TJ, Miller RJ. Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res. 2004 Apr 1;76(1):20-34 Abstract IH |
| Kayali AG, Van Gunst K, Campbell IL, Stotland A, Kritzik M, Liu G, Flodstrom-Tullberg M, Zhang YQ, Sarvetnick N. The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol. 2003 Nov 24;163(4):859-69 Full Text IH |
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