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| Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family and an amino acid in between the first 2 cysteines. Historically, the 360 amino acid chemokine receptor type 4 (CCR4) has been designated as C-C CKR-4, CC-CKR-4, CCR-4 and K5-5 and is 85% identical to murine CCR4 receptor. Chemokines TARC/CCL17 and MDC/CCL22 are ligands for CCR4. Specificity: Peptide sequence is <50% identical to other chemokine receptors in this region. Formulation: Liquid 200 µg of peptide affinity purified IgG in 10 mM KHPO4, 140 mM NaCl at 1.0 mg/ml with 1 mg/ml BSA and 0.1% sodium azide Quality Control: Immunohistochemistry on paraffin section of human spleen cells Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
IH on paraffin section of human spleen |
For Research Purposes Only |
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Citations and Applications |
| Yagi H, Seo N, Ohshima A, Itoh T, Itoh N, Horibe T, Yoshinari Y, Takigawa M, Hashizume H. Chemokine Receptor Expression in Cutaneous T cell and NK/T-cell Lymphomas: Immunohistochemical Staining and In Vitro Chemotactic Assay. Am J Surg Pathol. 2006 Sep;30(9):1111-9. Abstract IH |
| Ritter M, Goggel R, Chaudhary N, Wiedenmann A, Jung B, Weith A, Seither P. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62. Abstract IH |
| Luttichaux IV, Notohamiprodjo M, Wechselberger A, Peters C, Henger A, Seliger C, Djafarzadeh R, Huss R, Nelson PJ. Human Adult CD34() Progenitor Cells Functionally Express the Chemokine Receptors CCR1, CCR4, CCR7, CXCR5, and CCR10 but Not CXCR4. Stem Cells Dev. 2005 Jun;14(3):329-36 Abstract FC |
| Shadidi KR, Aarvak T, Henriksen JE, Natvig JB, Thompson KM.The chemokines CCL5, CCL2 and CXCL12 play significant roles in the migration of Th1 cells into rheumatoid synovial tissue. Scand J Immunol. 2003 Feb;57(2):192-8 Abstract IC |
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