|
|||||||||||||||||||||||||||||||||||
| Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation that are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid in between the first 2 cysteines. Historically, chemokine receptor type 8 has been designated C-C chemokine receptor type 8, CC-CKR-8, CCR-8, GPR-CY6, Chemokine receptor-like 1, CKR-L1, TER1, CMKBRL2, CC-chemokine receptor CHEMR1, and CDw198 antigen. Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this region. This antibody was not tested for cross-reactivity to mouse CCR8 receptor. Formulation: Liquid, 200 µg of peptide affinity purified IgG antibody in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide Quality Control: Immunocytochemistry on human K562 cells and /or Immunohistochemisrty on human spleen cells Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
Above: Immunohistochemistry on paraffin section of human spleen For Research Purposes Only |
|
||||||||||||||||||||||||||||||||||
Citations and Applications |
| Faaij CM, Lankester AC, Spierings E, Hoogeboom M, Bowman EP, Bierings M, Révész T, Egeler RM, van Tol MJ, Annels NE. A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease. Br J Haematol. 2006 Jun;133(5):538-49. Abstract FC |
| Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Int J Cancer. 2006 May 1;118(9):2147-57. Abstract FC |
| Gombert M, Dieu-Nosjean MC, Winterberg F, Bunemann E, Kubitza RC, Da Cunha L, Haahtela A, Lehtimaki S, Muller A, Rieker J, Meller S, Pivarcsi A, Koreck A, Fridman WH, Zentgraf HW, Pavenstadt H, Amara A, Caux C, Kemeny L, Alenius H, Lauerma A, Ruzicka T, Zlotnik A, Homey B. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J Immunol. 2005 Apr 15;174(8):5082-91. Full Text FC |
| Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, Revesz T. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004 Apr 1;103(7):2806-8 Full Text FC |
| Strasly M, Doronzo G, Capello P, Valdembri D, Arese M, Mitola S, Moore P, Alessandri G, Giovarelli M, Bussolino F. CCL16 activates an angiogenic program in vascular endothelial cells. Blood. 2004 Jan 1;103(1):40-9. Full Text N |
| Haque NS, Fallon JT, Taubman MB, Harpel PC. The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. Blood. 2001 Jan 1;97(1):39-45. Full Text N |
