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| Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation that are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid in between the first 2 cysteines. Historically, chemokine receptor type 8 has been designated C-C chemokine receptor type 8, CC-CKR-8, CCR-8, GPR-CY6, Chemokine receptor-like 1, CKR-L1, TER1, CMKBRL2, CC-chemokine receptor CHEMR1, and CDw198 antigen. Specificity: Peptide sequence is <50% identical to other chemokine receptors in this region. Formulation: Affinity purified IgG antibody in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide Quality Control: Immunocytochemistry on human K562 cells and/or Immunohistochemistry on paraffin sections of human spleen Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
Above: IH on paraffin section of human spleen |
For Research Purposes Only |
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Citations and Applications |
| Trebst C, Staugaitis SM, Kivisakk P, Mahad D, Cathcart MK, Tucky B, Wei T, Rani MR, Horuk R, Aldape KD, Pardo CA, Lucchinetti CF, Lassmann H, Ransohoff RM. CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages. Am J Pathol. 2003 Feb;162(2):427-38. Full Text IH |
| Iellem A, Mariani M, Lang R, Recalde H, Panina-Bordignon P, Sinigaglia F, D'Ambrosio D. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2001 Sep 17;194(6):847-53. Full Text IH |
