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| Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family and an amino acid in between the first 2 cysteines. Historically, chemokine receptor C-C chemokine receptor type 9 (CCR9) has been designated as C-C chemokine receptor type 9 (C-C CKR-9), CC-CKR-9, CCR-9, GPR-9-6, G-protein coupled receptor 28, and CDw199 antigen. Specificity: Peptide sequence is < 50 % identical to other human chemokine receptors in this peptide region. The antibody recognizes human CCR9 and is likely to cross-react to mouse CCR9 due to 75 % homology in this region. Formulation: Affinity purified IgG antibody in 200 ul of 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide Quality Control: Immunohistochemistry on human spleen Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
Immunohistochemistry on paraffin sections of human spleen For Research Purposes Only |
Anti-CCR9 Inhibition of TECK-Induced Activation of ES-2
TECK-Induced Activation of ES-2 |
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Citation and Application |
| Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, Revesz T. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004 Apr 1;103(7):2806-8. Full Text IH |
