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| D6 is expressed on the lymphatic endothelium and leukocytes. Defined as a "silent" chemokine receptor, D6 has no G coupling protein motifs. No signalling occurs upon chemokine binding and D6 functions as a scavenger receptor internalizing and degrading chemokines leading to a dampening of inflammatory processes. Specificity: Peptide sequence is < 50 % identical to other chemokine receptors in this region and cross-reactivity to mouse D6 was not tested. Formulation: CI0130 is liquid 200 µg of affinity purified antibody in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide. CI0171 is liquid 100 µg of biotin labeled affinity purified antibody in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide. Quality Control: Immunohistochemistry on human spleen Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
IH on paraffin section of human spleen CIO130P - Blocking Peptide to Antibody $95 USD per 100 µg |
For Research Purposes Only |
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Citation and Application |
| Neil SJ, Aasa-Chapman MM, Clapham PR, Nibbs RJ, McKnight A, Weiss RA. The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. J Virol. 2005 Aug;79(15):9618-24. Full Text FC |
