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| D6 is expressed on the lymphatic endothelium and leukocytes. Defined as a "silent" chemokine receptor, D6 has no G coupling protein motifs. No signalling occurs upon chemokine binding and D6 functions as a scavenger receptor internalizing and degrading chemokines leading to a dampening of inflammatory processes. Specificity: Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region. The antibody recognizes mouse D6 and was not tested for cross-reactivity to human D6. Formulation: Liquid 200 µg of peptide affinity purified IgG antibody in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide. Quality Control: Immunohistochemistry on mouse spleen cells and lung Storage: Freeze at -20° C. For long term storage freeze at -80° C. Stable for at least three years at -80° C. Avoid freeze-thaw cycles. CIO123P - Blocking Peptide to Antibody $95 USD per 100 µg
IH on paraffin section of mouse lung For Research Purposes Only |
IH
on paraffin section of mouse spleen |
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Citation |
| Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM. A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am J Pathol. 2008 May;172(5):1209-21 Full Text IH |
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