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DATASHEET Chemokine receptors are G protein-coupled receptors (GPCRs) that play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid in between the first 2 cysteines. Historically, chemokine receptor type 1 has been designated C-C chemokine receptor type 1, CC-CKR-1, CCR-1, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, HM145, LD78 receptor, and CD191 antigen. Specificity: Peptide sequence is < 50 % identical to other chemokine receptors in this region and has no cross-reactivity to mouse CCR1. Formulation: Liquid 100 ug of peptide affinity purified IgG antibody in 10 mM KHPO4, 140 mM NaCl with 1 mg/ml BSA and 0.1 % sodium azide. Quality Control: Immunocytochemistry on human peripheral blood leukocytes Storage: Freeze at -80 °C. Stable for at least 3 years when stored at -80 °C. Avoid freeze/thaw cycles.reeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
For Research Purposes Only |
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| References | |
1. |
Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 1993 Feb 12;72(3):415-25 Abstract |
2. |
Su SB, Mukaida N, Wang J, Nomura H, Matsushima K. Preparation of specific polyclonal antibodies to a C-C chemokine receptor, CCR1, and determination of CCR1 expression on various types of leukocytes. J Leukoc Biol. 1996 Nov;60(5):658-66 Abstract |
