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DATASHEET Chemokine receptors are G protein-coupled receptors (GPCRs) that play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid in between the first 2 cysteines. Historically, murine chemokine receptor type 3 (CCR3) has been designated as C-C CKR-3, CC-CKR-3, CCR-3, CKR3, Macrophage inflammatory protein 1-alpha receptor-like 2, MIP-1 alpha RL2, and CD193 antigen. Specificity: This antibody recognizes mouse CCR3 and the peptide sequence is < 50 % identical to other chemokine receptors in this region. Formulation: Liquid 200 µg of affinity purified antibody in 10 mM KHPO4, 140 mM NaCl with 0.1 % sodium azide and 1 mg/ml BSA Quality Control: Immunohistochemistry on paraffin sections of mouse spleen Storage: Freeze at -20 °C or colder. Stable for at least 3 years when stored at -80°C. Avoid freeze/thaw cycles. Above: Immunohistochemistry of CI0154 antibody to mouse CCR3 on paraffin section of mouse spleen |
For Research Purposes Only |
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Reference |
| Gao JL, Murphy PM. Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501 Full Text |
