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Human Toll-like receptor 4 (TLR4) |
Toll-like receptors (TLRs) are membrane proteins on many cells involved with innate immunity such as macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and endothelial cells. Ten different mammalian TLRs have been identified and all have distinct specificities for microbial ligands. Upon recognition of a microbial product, TLRs initiate a signaling pathway to activate innate immunity. TLR4 recognizes gram-negative bacterial and chlamydia associated lipopolysacharride (LPS) and HSP60.
Specificity: Peptide sequence is < 50 % identical to other human TLR receptors in this region. The antibody recognizes human TLR4, mouse, and rat TLR4.
Sequence Alignment:
LIQSFKLPEYFSNLTNLEHLDLSSNKIQSI Human TLR4
LI+SFKLPEYFSNLTNLEH+DLS+N+IQ+I
LIHSFKLPEYFSNLTNLEHVDLSYNYIQTI Rat TLR4
IQSFKLPEYFSNLTNLEHLDLSSNKIQSI Human TLR4
I+S+KLP+YFSNLTNL+H+DLS+N+IQ+I
IHSCKLPAYFSNLTNLVHVDLSYNYIQTI Mouse TLR4
Formulation: Liquid 200 µg of affinity purified antibody at 2 mg/mL in 10 mM KHPO4, 140 mM NaCl with 1 mg/mL BSA and 0.1 % sodium azide.
Quality Control: Immunohistochemistry on paraffin sections of human tonsil and mouse spleen
Storage: Freeze at -20° C. For long term storage freeze at -80° C. Avoid freeze-thaw cycles.
IH on paraffin section of human tonsil
IH on paraffin section of human spleen
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IH on paraffin section of mouse spleen
For Research Purposes Only