 |
Human Toll-like receptor 8 (TLR8) |
Toll-like receptors (TLRs) are membrane proteins on many cells involved with innate immunity such as macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and endothelial cells. Ten different mammalian TLRs have been identified and all have distinct specificities for microbial ligands. Upon recognition of a microbial product, TLRs initiate a signaling pathway to activate innate immunity. TLR8 recognizes viral associated single-stranded RNA.
Specificity:Peptide sequence is < 50 % identical to other human TLR receptors in this region. The antibody recognizes human TLR8 and mouse TLR8.
Sequence Alignment:
Human TLR8
ESFQGLQNLTKINLNHNPNVQHQNGN
ESFQ+LQNLTKI+LNHN++++QH+N+N
ESFQKLQNLTKIDLNHNAKQQHPNEN
Mouse TLR8
Human TLR8
ESFQGLQNLTKINLNHNPNVQHQNGNPGI
ESFQGLQNLTKINLNHNPNVQ+QNGNPG+
ESFQGLQNLTKINLNHNPNVQRQNGNPGM
Macaca TLR8
Formulation: Liquid 200 µg of affinity purified antibody at 1 mg/mL in 10 mM KHPO4, 140 mM NaCl with 1 mg/mL BSA and 0.1 % sodium azide.
Quality Control: IH on paraffin sections of human tonsil and mouse spleen
Storage: Freeze at -20° C. For long term storage freeze at -80° C. Avoid freeze-thaw cycles.
IH on paraffin section of human tonsil
|
||||||||||||||||||||||||||
|
IH on paraffin section of mouse spleen
For Research Purposes Only