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Chemokine receptors are G protein-coupled receptors (GPCRs) that play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family has an amino acid in between the first 2 cysteines. Historically, chemokine receptor type 1 has been designated C-C chemokine receptor type 1, CC-CKR-1, CCR-1, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, HM145, LD78 receptor, and CD191 antigen. Specificity: Since the peptide sequence shares less than 50% amino acid identity to other chemokine receptors in this region, this antibody only recognizes human receptor. Formulation: F(ab')2 IgG in PBS with 1 mg/ml BSA and 0.1% sodium azide Quality Control: Immunohistochemistry of human tonsil or spleen. Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles.
IH of paraffin embedded section of human tonsil enlarge
For Research Purposes Only |
IH of paraffin embedded section of human spleen enlarge |
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CIO101P - Blocking Peptide to Antibody per 100 µg
Citations and Applications |
| Schaller MA, Kallal LE, Lukacs NW. A Key Role for CC Chemokine Receptor 1 in T-Cell-Mediated Respiratory Inflammation. Am J Pathol. 2008 Feb;172(2):386-94. Full Text FC |
| Hannan NJ, Jones RL, White CA, Salamonsen LA. The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface. Biol Reprod. 2006 May;74(5):896-904. Full Text IH |
