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| Chemokine receptors are G protein-coupled receptors (GPCRs) and play a key role in inflammation and are characterized by similar sequences with a 4 cysteine motif. The C-C family has the first 2 cysteines linked together while the C-x-C family and an amino acid in between the first 2 cysteines. Historically, murine chemokine receptor type 4 (CCR4) has been designated as C-C CKR-4, CC-CKR-4, and CCR-4. Specificity: Peptide sequence is <50% identical to other chemokine receptors in this region. The antibody recognizes mouse CCR4 and has no cross-reactivity to human CCR4. Formulation: F(ab')2 IgG in KHPO4 buffer with 1 mg/ml BSA and 0.1% sodium azide Quality Control: Immunofluorescence or Immunocytochemistry on human peripheral blood leukocytes or human T-cell line Jurkat Storage: Freeze at -20° C. For long term storage freeze at -70° C. Avoid freeze-thaw cycles. For Research Purposes Only |
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CIO102P - Blocking Peptide to Antibody per 100 µg
Citations and Applications |
| Dudda JC, Simon JC, Martin S. Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets. J Immunol. 2004 Jan 15;172(2):857-63. Full Text FC |
| Kikuchi T, Crystal RG. Antigen-pulsed dendritic cells expressing macrophage-derived chemokine elicit Th2 responses and promote specific humoral immunity. J Clin Invest. 2001 Sep;108(6):917-27. Full Text IH |
