Capralogics, Inc., P.O. Box 356, Hardwick, MA 01037 USA
Phone (800) 975-6866 / (413) 477-6866 • FAX (413) 643-0067 • capralogics.com

HMG-CoA (HMGCR)

$295.00
SKU: CC0208
Synonyms: 
3-Hydroxy-3-methylglutaryl-CoA reductase, HMGCR

Western Blot: Human HMG-CoA (HMGCR). Sixty micogram of lysate<br />were used per each lane. The UT-2 cell line does not express HMGCR.

Specifications

Amount: 
250 ug
Host Species: 
Rabbit
Antigen: 
HMG CoA reductase catalytic domain fused to GST protein
Reactive Species: 
Human
Format/Conjugates/Purification: 
Protein A
Buffer & Formulation: 
Purified IgG in PBS with no preservatives
Storage: 
Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
Clone: 
Polyclonal

Applications

Western Blotting: 
1:1000
Comments: 

HMG-CoA reductase is a polytopic, transmembrane protein that catalyzes a key step in the mevalonate pathway, which is involved in the synthesis of sterols, isoprenoids and other lipids.

The extraction protocol used to demonstrate specific detection of HMGCR using CC0208 (Rabbit anti-Human HMGCR) antibody can be found in PNAC, August 24, 2010 and Blood, June 10, 2010

References: 

Eberhard Y, Gronda M Hurren R, Datti A, MacLean N, Ketela T, MoffatJ, WrantJL, Schimmer AD.  Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget 2011 Mar:2(3) 186-196 (WB) Full Text

Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ.   Dysregulation of the Mevalonate Pathway Promotes Transformation.  Proc. National Acad Sci USA 2010 Aug 24; 107 (34):15051-6. Epub 2010 Aug 9.  

James W. Clendening, Aleksandra Pandyra, Zhihua Li, Paul C. Boutros, Anna Martirosyan, Richard Lehner, Igor Jurisica, Suzanne Trudel, and Linda Z. Penn.  Exploiting the Mevalonate Pathway to Distinguish Statin-Sensitive Multiple Myeloma.  Blood, 2010 June 10; 115(23): 4787-97.

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