Capralogics, Inc., P.O. Box 356, Hardwick, MA 01037 USA
Phone (800) 975-6866 / (413) 477-6866 • FAX (413) 643-0067 • capralogics.com

anti-Adiponectin Receptor AdipoR1 N-terminus

$295.00
SKU: CI0163

IH Paraffin: ADPR1 N-terminus human liver (above). IH Paraffin: ADPR1 N-terminus IH Human muscle (below).

Specifications

Amount: 
200 ug
Host Species: 
Goat
Antigen: 
25 amino acid (aa) synthetic peptide SSHKGSVVAQGNGAPASNREADTVE corresponding to aa 2-26 of the N-terminal domain of AdipoR1
Reactive Species: 
Highly conserved suggesting multiple species
Format/Conjugates/Purification: 
Peptide Affinity Purification
Buffer & Formulation: 
Affinity purified antibody @ 1mg/ml in 10 mM KHPO4, 140 mM NaCl, BSA @ 1mg/ml and 0.1 % sodium azide
Storage: 
Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
Clone: 
Polyclonal

Applications

Western Blotting: 
1:1000
IHC: 
1:250 (paraffin sections)
Comments: 

Adiponectin receptor 1 (AdipoR1) is an integral membrane protein with seven transmembrane domains with an internal N-terminus and an external C-terminus. AdipoR1 is highly conserved among species and expressed by many cells. Skeletal muscle is rich source of AdipoR1. Obese humans have decreased expression of AdipoR1 in adipose tissue (AT). Weight loss leads to increased AdipoR1 in AT.

References: 

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.  J Clin Invest. 2006 Jul;116(7):1784-92. Full Text
Rasmussen MS, Lihn AS, Pedersen SB, Bruun JM, Rasmussen M, Richelsen B.  Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots.  Obesity (Silver Spring). 2006 Jan;14(1):28-35. Full Text
Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Peterfi C, Weisser M, Machicao F, Stumvoll M, Haring HU.   Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.  Diabetes. 2004 Sep;53(9):2195-201. Full Text
Yamauchi T, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.  Nature. 2003 Jun 12;423(6941):762-9.  Abstract

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